Origin of eukaryotic plasmalogen biosynthesis by horizontal gene transfer from myxobacteria

Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificancePlasmalogens are important membrane lipids in animals, yet their evolutionary origin has remained a puzzle due to their patchy distribution across the eukaryotic tree. We found that the core set of genes required for aerobic plasmalogen …