Paramyxovirus infection driven by heteromultivalent sialoglycotope binding

Proceedings of the National Academy of Sciences, Volume 123, Number 17, April 2026.
SignificanceHuman respiroviruses, a major cause of hospitalization in young children, bind to α2-3-linked sialic acid (2-3Sia) receptors, which are rare in the human upper respiratory tract (URT), their primary site of replication. Why do these viruses, in…