Pde4 mediates MHCII expression in oligodendroglia

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Proceedings of the National Academy of Sciences, Volume 123, Number 19, May 2026.
Significance This work reveals a glial pathway by which chronic psychosocial stress leads to maladaptive myelin and immune changes. We show that upregulation of Pde4b in stress-specific immune-like oligodendrocytes (ImOL) orchestrates cyclic adenosine…

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