Phenotypic CRISPR screens identify NLRX1 as an essential activator of the human mitochondrial permeability transition

Proceedings of the National Academy of Sciences, Volume 123, Issue 9, March 2026. <br/>SignificanceMitochondria utilize calcium to increase ATP synthesis. However, excessive matrix calcium activates the mitochondrial permeability transition (mPT), a process that permeabilizes the mitochondrial inner membrane and leads to cell death. While …