Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases

Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificanceThis study presents S-1117, a pan-IgG protease engineered using Seismic’s IMPACT platform to address the limitations of existing therapies in IgG-mediated diseases. The superior pharmacokinetic profile and the polypharmacology of S-1117, …