Polyserine domains are toxic and exacerbate tau pathology in mice

Proceedings of the National Academy of Sciences, Volume 123, Issue 1, January 2026. <br/>SignificanceThis study evaluates the toxic effects of polyserine domains in vivo. Polyserine and endogenous polyserine-containing proteins have been shown to enrich in tau aggregates across models and in human postmortem tissues. Further, polyserine …