PPP1R3G–RIPK1–ZBP1 axis activates early-stage apoptosis and late-stage necroptosis to promote doxorubicin-induced cardiotoxicity

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. <br/>SignificanceThis study identifies Protein Phosphatase 1 Regulatory Subunit 3G (PPP1R3G) as a key driver of doxorubicin-induced cardiotoxicity, acting by removing a protective molecular brake on cell death. We define a PPP1R3G–RIPK1–ZBP1 signaling axis …