Predicting the unseen: A diffusion-based debiasing framework for transcriptional response prediction at single-cell resolution

Proceedings of the National Academy of Sciences, Volume 122, Number 52, December 2025.
ImportanceUnderstanding how cells respond to gene disruptions is essential for uncovering the rules of gene regulation. Single-cell RNA sequencing combined with CRISPR-based disruptions has transformed this effort, but large-scale experiments…