Quantifying the fidelity of in vitro human cell culture systems using a biomedical foundation model

Proceedings of the National Academy of Sciences, Volume 123, Number 12, March 2026.
Significance This manuscript addresses the challenges associated with quantitative comparisons of cell types cultured in vitro versus their in vivo counterparts. Here, we use the intestinal epithelium as a model system to address this challenge. We have designed an in vitro culture platform…