Ras-mediated dynamic and biphasic regulation of cell migration

Proceedings of the National Academy of Sciences, Volume 122, Issue 30, July 2025. <br/>SignificanceThis study challenges the traditional view of Ras as only a positive regulator of cell functions via gene expression. Using optogenetics to rapidly modulate Ras activity inDictyostelium, we reveal a biphasic relationship: both excessive and …