Redefining Shiga toxin–induced human cell death as NLRP1- and gasdermin E-mediated pyroptosis

Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. <br/>SignificanceTreatment options for life-threatening kidney and intestinal diseases caused by EnterohemorrhagicEscherichia coli(EHEC)—affecting 265,000 people, especially children, per annum in the United States—are limited as antibiotics are …