Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains

Proceedings of the National Academy of Sciences, Volume 122, Number 48, December 2025.
SignificanceGrowing evidence implicates the prion mechanism in protein misfolding associated with other neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. The transmission of bovine prions to humans in the food chain is increasing…