Restoring the 14-3-3/CRAF regulatory interaction in Noonan syndrome using molecular glues

Proceedings of the National Academy of Sciences, Volume 123, Number 18, May 2026.
ImportanceCRAF kinase, a key component of the MAPK signaling pathway, is autoinhibited by phosphorylation at S259, which induces binding to the 14-3-3 adapter protein and formation of an inactive complex. In RASopathy Noonan syndrome (NS), CRAF and …