Retinol saturase in the mitochondria antagonizes IDH2 and GLUD1 acetylation to mediate heart repair

Proceedings of the National Academy of Sciences, Volume 123, Number 14, April 2026.
ImportancePromoting the proliferation of endogenous cardiomyocytes appears to be a promising strategy for cardiac repair. Here we reveal that Retsat activates cell cycle re-entry of cardiomyocytes and promotes cardiac regeneration independently of its canonical state…