SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands

Proceedings of the National Academy of Sciences, Volume 122, number 31, August 2025.
The basics of significant cytosine are significant are essential components of mammalian genomes, but the way they are distributed in double -strand DNA remain unclear. Here, we report a method to simultaneously sequence the two most abundant modified modified bases – 5 -…