Self-adjuvanting α-helical polypeptide simultaneously delivers neoantigen mRNAs and activates dendritic cells to eradicate tumors

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. <br/>SignificanceMessenger RNA (mRNA)-based cancer vaccines have long been sought, but are limited by the modest therapeutic efficacy. One central challenge lies in the development of mRNA carriers that not only facilitate the expression of mRNA-encoded tumor …