Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity

Proceedings of the National Academy of Sciences, volume 123, number 11, March 2026.
SignificanceSub-slow (<0.1 Hz) overall brain activity in the resting state has recently been associated with aging and Alzheimer's disease (AD), likely due to its potential role in sleep-dependent clearance of brain metabolic waste. We show that total sleep...