Spatiotemporal control of PIWI compartmentalization by mitochondrial scaffolds defines pachytene piRNA pathway organization

Proceedings of the National Academy of Sciences, Volume 123, Number 20, May 2026.
SignificancePachytene piRNAs are essential for male fertility, but how their biogenesis is spatially organized within germ cells remains unclear. This study identifies mitochondrial scaffolding proteins that govern the recruitment and compartmentalization of…