Stretch and flow at the gliovascular interface: High-fidelity modeling of astrocyte endfeet

Proceedings of the National Academy of Sciences, Volume 123, Number 11, March 2026.
SignificancePerivascular spaces, formed by the endfeet of astrocytes enveloping the vascular system, are high conduit pathways for the flow and removal of brain fluid. Vascular pulsations drive this flow, but the resulting mechanical interactions at the gliovascular pathways…