Structural basis of transcription-coupled RNA damage by incorporation of oxidized ribonucleotides

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. <br/>SignificanceCells are continuously exposed to oxidative stress, which lead to oxidation damage on DNA, RNA as well as nucleotide pools. However, the formation of oxidative RNA damage and the impact of an oxidized ribonucleotide pool on transcription …