Substrate-dependent activation of LONP1 informs on proteolytic regulation and ATPase motor function

Proceedings of the National Academy of Sciences, Volume 122, Issue 42, October 2025. <br/>SignificanceThe AAA+ protease LONP1 plays a critical role in regulating mitochondrial proteostasis by removing damaged and unfolded matrix proteins, including certain privileged folded substrates. To better understand LONP1 substrate selection and motor …