Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain

Proceedings of the National Academy of Sciences, Volume 122, Issue 26, July 2025. <br/>SignificanceChronic pain is a major global health issue with few effective long-term treatments. While abnormal signaling in the anterior cingulate cortex (ACC) is known to drive chronic pain, the underlying mechanisms remain unclear. We identify a loss …