Synthetic SIGLEC9-based chimeric switch receptor augments the efficacy of CAR macrophages against glioblastoma

Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificanceGlioblastoma multiforme (GBM) is a lethal brain tumor for which current immunotherapies provide little durable benefit. Tumor-associated macrophages (TAMs) are abundant in GBM but are driven toward an immune-suppressive state by …