TAPT1 interacts with SUCO to maintain the homeostasis of newly synthesized proteins and brain development in mice

Proceedings of the National Academy of Sciences, Volume 122, Number 50, December 2025.
Significance Genetic mutations in TAPT1 cause complex skeletal dysplasia and abnormal brain structure. Here, we demonstrate that inactivation of Tapt1 in the brain results in profound neurodevelopmental abnormalities, culminating in severe microcephaly, motor…