Tetraspanin TSP-12 and SUP-17/ADAM10 exhibit cell type–specific codependence for trafficking through the Golgi

Proceedings of the National Academy of Sciences, Volume 123, Number 1, January 2026.
SignificanceC8 (TspanC8) tetraspanins are known to bind and promote cell surface localization of ADAM10, a conserved transmembrane metalloprotease essential for metazoan embryonic development and human health. However, in vivo functionality…