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Subtype-specific structural features of the hearing loss–associated human P2X2 receptor

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Proceedings of the National Academy of Sciences, Volume 122, Issue 37, September 2025. <br/>SignificanceThe P2X2 receptor (P2X2R) is an adenosine triphosphate (ATP)-gated ion channel with few small-molecule modulators that exhibit poor pharmacological properties. It is known to be involved in the auditory system and has been proposed as a drug …

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