The functional dynamics of FicD’s TPR domain are modulated by the interaction with ATP and BiP

Proceedings of the National Academy of Sciences, Volume 122, Issue 34, August 2025. <br/>SignificanceThe heat shock protein 70 family, including the ER-specific homolog BiP, is vital for protein homeostasis. BiP is regulated posttranslationally via AMPylation by FicD, whose crystal structures reveal conformational variability and suggest …