The liver talks back: NPY orchestrates attraction of cancer cells and CHK2-dependent clonogenicity in the metastatic niche

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. <br/>SignificanceApproved RNA interference (RNAi) therapeutics marked groundbreaking advances. Yet, the clinical translation of RNAi for cancer treatment remains unrealized—largely due to the predominant delivery of siRNAs to hepatocytes. Our study uncovers a …