Trem2 exacerbates ischemic brain injury through Gpnmb in a photothrombotic stroke model

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. <br/>SignificanceStroke is a leading cause of death and disability, with microglia-driven inflammation as a key contributor to brain injury. The microglial receptor Trem2 has shown inconsistent roles: protective in a classic stroke model but associated with …