Lineage tracing of both quiescent G0 and active Hoxb5+ LT-HSCs that actively contribute to homeostatic mouse hematopoiesis
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Proceedings of the National Academy of Sciences, Volume 122, Number 49, December 2025.
SignificanceProspectively isolated HSCs regenerate long-term hematopoiesis via transplantation into irradiated hosts. Hoxb5 is expressed only in LT-HSCs. In this study, LT-HSCs are the first cells marked by Hoxb5 lineage tracing and actively participate in…
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