USP14-mediated metabolic competition impairs CD8+ T cell immunosurveillance in hepatocellular carcinoma

Proceedings of the National Academy of Sciences, Volume 122, Issue 38, September 2025. <br/>SignificanceImmunotherapy based on CD8+ T cells benefits only a fraction of hepatocellular carcinoma (HCC) patients, creating an urgent need for strategies that can overcome resistance. In this study, we identified tumor-intrinsic USP14 as a key mediator …