Versatile SMAD2 and SMAD3 epitope–tagged mouse models for genomic profiling of TGFβ signaling: Uncovering GDF9–SMAD2/3 targets

Proceedings of the National Academy of Sciences, Volume 123, Issue 14, April 2026. <br/>SignificanceOur study reports the generation and characterization of two mouse models in which endogenous SMAD2 and SMAD3 are epitope-tagged, enabling high-resolution, genome-wide mapping of SMAD2/3 complexes under physiological conditions. These models …