Week 2 NFL odds, lines, betting picks, spreads: 2025 predictions: Model backs Cowboys, Cardinals
The calendar of week 2 of the NFL gives us our first match with a two -digit spread from the NFL with Ravens against Browns (+12.5). It is despite eight of the last nine meetings between these teams decided by 10 points or less, Cleveland won squarely in two of the last three. If you prefer the spreats of the week 2 of the NFL which are much thinner, there is no shortage, including the double head on Monday evening. Houston is a favorite of the house of 2.5 points on Tampa at 7 p.m. HE on Monday, while the loaders are road favorites from 3.5 points against Vegas at 10 p.m. HE.
Other expected clashes on which the bets of week 2 of the NFL include cowboys against the giants (+5.5) and a revenge of the Super Bowl in the chefs against the Eagles (-1). The motivation factor will be at a record level for Kansas City, because it should not be underestimated this during the week of the NFL choices of the week. All the NFL lines of the week 2 updates are listed below, and the advanced computer model of Sportsline has all the advice of Paris NFL and the predictions of the NFL you need to make the best choices of the NFL of week 2 now.
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The model, which simulates each game of the NFL 10,000 times, is up much more than $ 7,000 for $ 100 players on the most rated NFL choices since its creation. The model is on a 33-17 race on the best rated choices dating from 2024. Anyone according to its Paris choices on the NFL in sports books and on Paris sites could have seen strong returns.
Now he turned his attention to the last NFL rating lines of the week 2 and Paris NFL and locked the choices of Paris for each NFL match. Head here to see each choice.
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Top Week 2 NFL Predictions
We can tell you that one of the choices of the NFL the strongest week 2 of the model is that the cowboys (-6, 44.5) cover propagation at home compared to the giants. Dallas beat New York in eight consecutive games, many of them being the variety of eruption. Cowboys have an average of 25.7 -point margin against New York in the last three games that Dak Prescott started in the series, and even Cooper Rush led a 7 -point victory over the Giants a year ago.
Despite the defeat of the kick -off match, Dallas looked impressive against the defending champion Eagles, in which the cowboys covered. Meanwhile, New York is already planning a quarter change after Russell Wilson made only 46% of his attempts during a 21-6 defeat against Washington. The giants are only 4-18 consecutive during their last 22 games, which dates back to the 2023 season. The Dallas model dominating compared to the spread much greater than 50% of the time. See which other teams to choose here.
Another one of its Week 2 NFL predictions: the Cardinals (-6.5, 45.5) cover at home versus the Panthers in almost 60% of simulations. The Bryce Young that had a strong finish to the 2024 season didn’t appear to start off the 2025 NFL season in an 16-point loss to a Jaguars squad that was 4-13 a year ago. Young had three turnovers, compared to just one touchdown, and completed barely over 50% of his pass attempts. He also didn’t get much help from his defense which didn’t register any sacks and allowed Jacksonville to rush for 200 yards.
As for Arizona, it both won and covered on the road versus the Saints, with the trio of Kyler Murray, James Conner and Trey Benson combining for 146 rushing yards. Murray also threw a pair of touchdowns, and the Cards played turnover-free ball in a hostile environment. Arizona will return home on Sunday, giving a massive edge to the Cardinals as Young is 1-15 straight-up in his NFL career on the road. The model backs the Cards (-6.5) to cover also says the Over hits almost 60% of the time. See which other teams to pick here.
How to make Week 2 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 2 NFL schedule and just revealed six coveted A-rated spread picks, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what NFL picks can you make with confidence, and which six teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 2 NFL betting odds, lines, live spreads, scores
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