When alternative becomes essential: The role of mitochondrial glycerol-3-phosphate dehydrogenase

Proceedings of the National Academy of Sciences, Volume 123, Issue 9, March 2026. <br/>Complex I is known as the primary entry point for electrons within the mitochondrial electron transport system (ETS). However, the glycerol-3-phosphate (G3P) shuttle, composed of cytosolic and mitochondrial G3P dehydrogenase (cG3PDH and mtG3PDH, …