Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes

Proceedings of the National Academy of Sciences, Volume 123, Number 20, May 2026.
SignificanceThe C4A gene copy number is associated with schizophrenia risk in genome-wide association studies of individuals of European ancestry. Higher expression of the C4A gene is associated with higher levels of synaptic pruning in the brain. …