Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms

Proceedings of the National Academy of Sciences, Volume 122, Number 44, November 2025.
SignificanceOur study reveals that early inhibition of FKBP51, a stress axis modulator, at the onset of joint injury provides lasting pain relief and significantly delays or prevents sex-dependent emotional comorbidities. On the other hand,…