Calsyntenin-3 suppresses inflammation via inhibition of TLR N-glycosylation and membrane localization

Proceedings of the National Academy of Sciences, Volume 123, Number 12, March 2026.
ImportanceUncontrolled inflammation is the cause of many diseases. Here, we identify calsyntenin-3 (CLSTN3) as an endogenous brake on TLR-triggered inflammation by impairing N-glycosylation and membrane translocation of TLRs. Decreased CLSTN3 expression…