Chiral inversion mutagenesis identifies geometrically constrained residues within self-associating low-complexity domains

Proceedings of the National Academy of Sciences, Volume 123, Issue 19, May 2026. <br/>SignificanceThis study identifies a critical role for amino acid side chain chirality in low-complexity domain (LCD) self-association. Using synthetic protein chemistry, we introduce targeted L-to-D amino acid inversions in LCDs without altering side …