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Guide DNA — not RNA — expands the CRISPR toolkit

https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c

Nature Biotechnology, Published online: 15 May 2026; doi:10.1038/s41587-026-03138-9

Cas12 nucleases can use guide DNA instead of guide RNA, which switches their targets from DNA to RNA.

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