HOP2–MND1 chaperones a diffusing DMC1–ssDNA complex to survey dsDNA for homology recognition during meiotic recombination

Proceedings of the National Academy of Sciences, Volume 123, Number 9, March 2026.
ImportanceDuring meiosis, cells must precisely find matching DNA sequences to repair breaks. How this “homology search” works is unclear. Using optical tweezer-based single-molecule imaging, we show that the recombination protein DMC1, when…