NAT10/ac4C drives intrahepatic cholangiocarcinoma by suppressing transposable elements via chromatin remodeling

Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThis work uncovers how a specific chemical modification on RNA, driven by the enzyme N-acetyltransferase 10, promotes a deadly liver cancer. We found that this modification stabilizes a key message that controls chromatin, leading to the …