Oxidative pentose phosphate pathway is required for T cell activation and antitumor immunity

Proceedings of the National Academy of Sciences, Volume 122, Number 49, December 2025.
ImportanceThe most common human enzyme deficiency concerns glucose-6-phosphate dehydrogenase (G6PD), the enzyme involved in the pentose phosphate oxidative pathway. A slight G6PD deficiency protects against malaria to the detriment of fragile red blood…