Sister chromatid separation determines the proliferative properties upon whole-genome duplication via homologous chromosome arrangement

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. <br/>SignificanceWhole-genome duplication (WGD), doubling of cellular content through skipping cell division after DNA synthesis, drives cellular diversification in development, aging, tumorigenesis, or evolution. While various mechanisms of WGD are featured …