The identification of potent nonopioid analgesics and their potential for perioperative use

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. <br/>SignificanceSodium channel has been considered as one of the most promising nonopioid analgesic targets in both academic and industrial worlds to address the opioid-related crisis. The prevailing strategy is to develop subtype-specific sodium channel …