Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes

Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificanceMicroscale neural probes are central to next-generation brain–machine interfaces, yet how they physically penetrate the living brain remains poorly quantified. Using a high-sensitivity force sensor integrated with real-time microscopy, we …