Cytochrome P450 1B1 directs pathogenic Th17 cell generation and autoimmune disease by fine-tuning redox homeostasis and mitochondrial integrity

Proceedings of the National Academy of Sciences, Volume 123, Issue 18, May 2026. <br/>SignificanceTh17 cells comprise pathogenic and nonpathogenic subsets, which are involved in autoimmunity and tissue homeostasis, respectively. Identifying factors that drive pathogenic Th17 generation is key for treating autoimmune diseases. Here, we …