Microtubule remodeling by the innate immune factor Trim69 compromises dynein-dependent migration of HIV virion cores toward the nucleus

Proceedings of the National Academy of Sciences, Volume 122, Issue 41, October 2025. <br/>SignificanceMicrotubules (MTs) are highways for the transport of voluminous cargo. While numerous examples in the literature have illustrated how viruses use MTs, we had previously identified Tripartite motif protein 69 (Trim69) as the first innate immune …