Intracellular pH regulates ubiquitin-mediated degradation of the MAP kinase ERK3

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Proceedings of the National Academy of Sciences, volume 122, number 43, October 2025.
SignificanceExtracellular signal-regulated kinase 3 (ERK3) is an atypical member of the mitogen-activated protein (MAP) kinase family. Unlike most kinases, ERK3 is an unstable protein whose constitution is degraded in proliferating cells. However, the…

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